MMJ - A Journal by MIMER Medical College, Pune, India

1.From the Editor's Desk

From the Editor's Desk

Sontakke Madam
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1] [No. of Hits: 609]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.1]


It is my proud privilege to announce the publication of first issue of MIMER Medical Journal on the occasion of 5th Annual Research Society Conference of MIMER Medical College, Talegaon Dabhade. I would like to take this opportunity to acknowledge the efforts taken by all the authors who have put their heart in the journal and have considered it worthy for publication of their good research work. Selection, editing and compilation of selected articles would not have been possible without the untiring & dedicated approach of the members of the editorial board, advisors & peer reviewers. I am sure that over the years the journal shall rise to great academic caliber and shall be referred at National & International platform.

2.Review Article

Markers of Bone Metabolism

A.N. Sontakke
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-17] [No. of Hits: 1051]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.2]


Bone turnover markers are protein originating from activity of osteoblasts and osteoclasts or fragments released during the formation and degradation of Type I collagen. Biochemical markers of bone resorption and formation are being intensively studied. Measurement of several of there molecules in serum and urine provide a valuable indication of ongoing homeostatic bone processes. Markers currently used in clinical practices are serum CTx, BAP and PINP. These markers are dynamic and reflect the resorption and formation rates. Current evidence suggests that the markers may be useful in conditions such as osteoporosis for monitoring the response to antiresorptive therapy (ART). Effective ART is associated with a bone marker reduction of 20 to 80% of the basal levels. As opposed to this other diagnostic modalities like dual energy X-ray absorptiometry (DEXA) need 1 to 3 years for observing the response to ART. In conjuction with BMD the biochemical markers can identify individuals at risk of osteoporosis. The limitations of biochemical markers as diagnostic tools can be minimised by measurement of several indices at a time as well as serial measurement of these indices.

3.Review Article

Why is India the world's stillbirth capital: causes and solutions?

Vaishali Korde-Nayak
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-14] [No. of Hits: 3996]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.3]


A stillbirth is a baby born with no signs of life at or after 28 weeks’ gestation, while preterm births are those which occur between 28 weeks to 32 weeks of gestation. Approximately 3.2 million stillbirths occur annually in low- and middle-income countries. The aim of this paper is to review the present status of the stillbirths and identify the underlying factors of stillbirths in India. A search of PubMed and other search engines were conducted to retrieve the literature pertaining to neonatal and perinatal health in India. It was found that women face many difficulties due to accessibility, availability, affordability and quality issues when utilizing healthcare facilities during pregnancy. Several studies based on stillbirths also revealed the social aspects of perinatal grief. Stillbirths are bounded by high family pressures and social stigma. A review also revealed that half of all stillbirths occur in India, Pakistan, Nigeria, China and Bangladesh alone. These countries also account for a high number of maternal and newborn deaths. India has highest number of stillbirths in the world – the rates range from 20 to 66 per 1000 births in different states. It was also found that healthcare and socio-cultural factors contribute to the increase in the number of stillbirths in India. These issues highlight the need for urgent action and interventions to be taken by the government and other organization to improve the situation of stillbirths in India. Early neonatal deaths and stillbirths usually have obstetric causes, and are largely preventable if good quality obstetric care is made available at the right time. Initiatives for strengthening the information management system at the grassroots level to report stillbirths on a regular basis are necessary to improve the neonatal health indicators in India.

Keywords: Stillbirths, Socio-economic factors.

4.Original Research Article

Prevalence and Antimicrobial Susceptibility Pattern of Bacterial Isolates from Blood Cultures of Hospitalized Patients in a Rural Tertiary Care Hospital: A 10 years Study.

Sandhya Kulkarni
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-20] [No. of Hits: 615]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.4]


Background- Bloodstream infections (BSI) are associated with significant mortality and morbidity worldwide.

Aims- i) To investigate bacteria isolated from blood cultures.
ii) To determine the antimicrobial susceptibility pattern of these bacterial isolates.
This is a retrospective study of blood samples received in the department of microbiology over a period of 10 years.

Materials and Methods- The bacterial isolates were identified by standard microbiological techniques andantimicrobial susceptibility testing was done by Kirby –Bauer method.

Results- During the study period, 2063 blood culture samples were analyzed. 720 (34.9%) samples were culturepositive. From 720 culture positive samples, 745 isolates were obtained of which 452(60.67%) were Gram-positive and 293(39.33%) were Gram-negative bacteria.
Most of the culture positive samples were of mono-microbial etiology (97.36%) and only from 19(2.64%) samples more than one organism were isolated.
The most predominant organism we isolated was Staph. aureus (55.43%).
More than 75% of Gram positive isolates were sensitive to Linezoloid (80.12%), Levofloxacin (78.5%), and Ampicillin-Sulbactum (76.64%). Among the group of Gram-negative organisms, the best overall sensitivity was noted to Gatifloxacin (70.67%) and the highest resistance was noted against Cefuroxime (95.45%), Cefadroxil (90.38%) and Amoxyclav (87.5%).

Conclusion- Staph. aureus was the most predominant isolate. Most of the isolates showed a variable degree of resistance to commonly tested antibiotics. The periodic evaluation of bacterial isolates and their antimicrobial susceptibility testing will help in selecting antibiotics to treat septicemia patients. This study seems to be helpful in providing guidelines to choose an effective antibiotic in cases of septicemia.

Key words- Septicemia, Bacterial isolates, Antimicrobial susceptibility

5.Original Research Article


Sangeeta B. Trimbake, Dr. A.N.Sontakke
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-11] [No. of Hits: 562]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.5]


BACKGROUND: Polycystic ovarian syndrome is the most common cause of infertility in women. Polycystic ovarian syndrome (PCOS) is a syndrome of ovarian dysfunction that is characterized by anovulation, hyperanderogenism. More over the association of PCOS with obesity and insulin resistance increases the risk of developing cardiovascular disease. Hence the study was planned to estimate the levels of lipid profile in PCOS.

OBJECTIVES: Assessment of serum lipid profile in PCOS.

MATERIAL AND METHODS: 30 clinically diagnosed PCOS patients and 30 age and sex matched controls were enrolled in the study.

RESULT AND CONCLUSION: There was a significant rise in serum total cholesterol, LDL-C (P <0.001), triacylglycerol P <(0.05) and a significant fall in HDL-C ( P < 0.05) levels of PCOS women as compared to controls. The dyslipidaemia associated with women having PCOS may contribute to the risk for developing atherosclerosis.
Hence it can be concluded that women with PCOS should be screened for lipid profile. This can be helpful in assessing the risk of coronary artery disease in these women. The same can be reduced by counseling the PCOS women regarding life style and dietary modifications.

KEY WORDS: Total cholesterol, LDL-C, HDL-C, dyslipidaemia, PCOS.

6.Original Research Article


Nutan Yogesh Chaudhari, Dr. A.N. Sontakke
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-11] [No. of Hits: 753]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.6]


BACKGROUND AND AIMS: Rheumatoid arthritis (RA) is characterized by local and systemic effects of inflammation and osteoarthritis (OA) is an inflammatory degenerative disorder of joint. A wide range of biochemical markers are implicated directly or indirectly to pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA). The exact oxidant and antioxidant status is not clear. Our aims were to estimate serum levels of lipid peroxidation in terms of malondialdihyde (MDA) and serum levels of antioxidants (in terms of vitamin E and reduced glutathione) rheumatoid arthritis and osteoarthritis patients and compare them with the levels in normal healthy controls.

MATERIALS AND METHODS: A study was performed in the department of biochemistry at M.I.M.E.R. Medical College, Talegaon (D), Pune. Serum levels of lipid peroxidation status (MDA) and antioxidants (vitamin E and reduced glutathione) were estimated by spectrophotometric methods in thirty patients of RA and OA each. Age and sex matched thirty healthy controls were also included in the study and serum levels of same parameters were also measured. Statistical analysis was performed by using the student unpaired t- test.

RESULTS: serum levels of MDA was significantly increased (p<0.001) while serum levels of vitamin E and reduced glutathione were significantly decreased (p<0.001) in RA and OA as compared to healthy controls and in that especially MDA was more elevated (p<0.001) in RA than OA. Negative correlation was established between MDA and vitamin E (r = -0.42) and reduced glutathione(r = -0.41) in RA.

Conclusion: Lipid peroxidation end product MDA and antioxidants like vitamin E and reduced glutathione showed statistically significant differences between controls and RA and OA patients which may have clinical utility in the management and administration of specific treatment to rheumatoid arthritis and osteoarthritis .

ABBREVIATIONS: RA - Rheumatoid arthritis, OA - Osteoarthritis, MDA - Malondialdihyde

KEYWORDS: Rheumatoid arthritis, osteoarthritis, vitamin E, reduced glutathione, malondialdihyde

7.Original Research Article

Assessment of the availability and need of private toilets in Maval Area

Dr (Mrs) Bandana Patnaik, Dr (Mrs) Swati S Raje, Mr Sandeep Tilekar
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-12] [No. of Hits: 494]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.7]


Lack of toilets leads to various problems in addition to health hazards. Various efforts have been made by Government to improve the sanitary conditions in the country. One of the major initiative is Intensive campaign for awareness generation and health education to create a felt need for personal, household and environmental sanitation facilities. With this background, a survey was done to assess the availability and need of private toilets in Maval Area and its association with socioeconomic factors. Activities were undertaken to increase the awareness about need of private toilets and impact of these activities was assessed after 6 months.
It was observed that in spite of 96% of the population being aware about diseases spread by unhygienic sanitary conditions, private latrines were owned by 45.6% of population. It was further noted that 16% of those who have private toilets also go for open air defecation. Financial disability was cause of not having private toilets for 31% people. Awareness improved marginally after 6 months of health awareness campaigns. Consistent efforts in this direction are needed to reach the goal of “swachha bharat abhiyaan”.

8.Original Research Article


[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-11] [No. of Hits: 753]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.8]


INTRODUCTION Old age should be regarded as normal , inevitable biological phenomenon. Life expectancy has risen and is expected to go on rising in almost every part of the world. In order to remain physically fit , well into later life, they should be aware of the problems faced in old age. Thus a study was conducted to assess the knowledge about the diseases and problems faced in this age group.


1. To assess the knowledge about various problem faced by the old age people.
2. To identify the problems of the old age people.

MATERIAL AND METHODS Study population consisted of geriatric people residing in area covered under UHTC of MIMER Medical College. Data collection was done using a pre-structured questionnaire from geriatric people attending OPD at UHTC.

RESULTS Study sample consisted of 60 people in the age group 40-86. 76.6 of geriatric population had the knowledge about different problems in the study sample. Awareness was present about only few highly common problem such as cataract , high blood pressure and arthritis . Very few of them were knowing about hearing loss , calcium deficiency and depression . There was no significant difference about the knowledge regarding health problems and exercise between males and females. Significantly more males felt the need of immunization in old age.

CONCLUSION Though the geriatric population are aware of the problems of hypertension , cataract and arthritis are very few knew about the other common problems. Hence there is need of increasing the awareness of the other common problems by health education.

9.Case Report


Dr.Dattesh Gore, Dr Megha Sonawane, Dr Anita Kulkarni Dr Shilpa Gurav
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-14] [No. of Hits: 951]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.9]


Retropharyngeal abscess possesses a great challenge to the anaesthesiologist due to the involvement of airway. Here we present to you a case of unanticipated difficult airway due to the retropharyngeal abscess which in itself was an incidental finding.
A six years old male child of 15 kg, presented with complaints of fever since 5 days and swelling in the right supraclavicular region noticed by the mother since last two days. She gave a history of recent onset of snoring. The neck swelling was diagnosed to be an abscess. The child was posted for incision and drainage of the same on an emergency basis.
On examination Patient was found to be febrile. Pulse rate was 140 beats /min. Oxygen saturation 99 % on room air. A swelling was seen in the right supraclavicular region. We planned to give general anesthesia for the procedure. After giving routine anesthetic agents patient started desaturating and mask ventilation became increasingly difficult. Patient was unable to maintain saturation even after airway maneuvers. Laryngoscopy was done and it was found that the posterior pharyngeal wall was bulging and obscuring almost the entire view of the larynx. A Cormack Lehane grade 3 i.e. only the tip of the epiglottis was visualized. We failed to intubate after two attempts and thus ventilator support was not acheived.
The pharyngeal bulge was immediately interpreted to be a retropharyngeal abscess and the supraclavicular swelling was in fact a tracking of the retropharyngeal abscess. Promptly an incision was taken on the neck swelling and the abscess drained externally. Following which the pharyngeal bulge collapsed. The larynx was now visualized. Airway was thus secured and 100% saturation achieved. Rest of the Intraoperative and postoperative period was uneventful.

KEYWORD: Retropharyngeal abscess, unanticipated difficult airway, difficult airway management.

10.Case Report

Intrauterine fetal demise of one twin baby and survival of the fittest”

Dr. Sushma Sharma, Dr. Shraddha D. Patil
[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-9] [No. of Hits: 1630]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.10]


We report a case which aims to highlight how multiple problems may exist in a single patient, yet can be managed with a favourable outcome. This patient of ours had infertility, RPL, genital TB. After successful treatment of infertility and TB, she had intrauterine demise of 1 baby of twin, thereby presenting multiple challenges, yet had a good outcome.

Key Words: RPL, Demise of 1 twin.

11.Case Report

Isolated Muscular Cysticercosis; a Diagnostic Challenge, a Case Report.

[Year:2017] [Month:January-June] [Volume:1 ] [Number:1] [Pages No:1-8] [No. of Hits: 736]
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  • [Abstract]
  • [DOI : 10.15713/ins.mmj.11]


Cysticercosis is a parasitic tissue infection caused by dissemination of the larval form of the pork tapeworm Taenia solium. It is highly prevalent in the developing countries. It is endemic in areas of pork consumption, poor hygiene and low socio-economic conditions. Human cysticercosis occurs by ingestion of eggs from contaminated water and vegetables. The human then becomes an accidental intermediate host, with development of cysticerci within organs. Isolated muscular involvement is rare with only few cases have been reported in the literature. We report a case of isolated cysticercosis of the skeletal muscle that presented a diagnostic challenge. It was accurately diagnosed on ultrasound and Magnetic Resonance (MR) imaging, the patient’s infection was managed with oral anthelminthic and symptomatic treatment without the need of operative intervention..

Keywords: Cysticercosis, tapeworm, albendazole, MRI